The drug should not be used during pregnancy except in cases where the potential benefit of treatment of the mother than the potential risk to the developing anastrozole 1 mg fetus. Lactation It is not known whether xylometazoline or its metabolites into breast milk, so the drug should not be used during breastfeeding.
Dosing and Administration
Children aged 2-6 years
• Unless directed otherwise by a single dose of the drug Tizin Xylo in the form of a nasal spray 0.05% dosed in each nostril 1-2 times a day.
Adults and children of school age (older than 6 years) • 3 times per day is administered by a single dose of the drug in the form of a Xylo Tizin 0.1% nasal spray metered into each nostril. The dose depends on the individual sensitivity of the patient and the clinical effect. Xylometazoline nasal dosing spray should not be used more than 5-7 days, if the doctor did not recommend a different treatment duration. After the completion of drug treatment may be administered again in just a few days. With regard to the duration of use in children always consult with a physician.
General recommendations for the introduction
Remove the protective cap. Before the first application several times to press the nozzle until a uniform cloud. The vial is ready for use.In applying the press once .The drug is inhaled through the nose. If possible, keep the spray bottle upright.Do not spray horizontally or downwards. After drinking a bottle cap close.
Tizin Xylitol can cause transient slight irritation of the nose (burning), paresthesia, sneezing and hypersecretion in susceptible people.
In some cases, the drug may experience increased swelling of the nasal mucosa (reactive hyperemia).
Prolonged or frequent use of xylometazoline anastrozole 1 mg or use it in high doses can cause a burning sensation in the nose or mucous membranes dry and reactive congestion with the development of medical rhinitis.This effect can be observed even after 5-7 days after completion of treatment, and long-term use can cause irreversible damage to the mucous membrane with formation of crusts (dry rhinitis).
In very rare cases, there may be headache, insomnia or fatigue, depression (with a long used in high doses).
in rare cases, local intranasal application may be accompanied by systemic sympathomimetic effects, such as palpitations, tachycardia, arrhythmias, increased blood pressure, blurred vision.
Symptoms of intoxication
overdose or accidental intake of the drug inside can cause the following symptoms: dilated pupils, nausea, vomiting, cyanosis, fever, spasms, tachycardia, cardiac arrhythmias, collapse, cardiac arrest, hypertension, pulmonary edema, respiratory failure, mental disorders.
In addition The following symptoms may occur: suppression of the central nervous system, accompanied by drowsiness, decrease in body temperature, bradycardia, shock-like hypotension, apnea and coma. intoxication Treatment Use of activated charcoal, gastric lavage, artificial respiration with the introduction of oxygen. To lower blood pressure used phentolamine 5 mg slow intravenous saline or 100 mg orally. Vasopressor agents are contraindicated. If necessary, apply anti-pyretic and anti-convulsants.
Interaction with other drugs
The simultaneous use of anastrozole 1 mg or tranylcypromine tricyclic antidepressants can cause increases in blood pressure due to cardiovascular effects of these substances.
Prolonged use of sympathomimetic overdose and providing dekongestivnoe action may lead to reactive hyperemia nasal mucosa.
The phenomenon of recoil can cause airway obstruction that leads to the patient again begins to use the drug or even permanently. This can lead to chronic swelling (rhinitis medicamentosa), and eventually even to atrophy of nasal mucosa (ozena).
In the case of chronic rhinitis drug anastrozole 1 mg and 0.1% may be used only under medical supervision, given the risk atrophy of the nasal mucosa. Hyersensitivity to benzalkonium chloride, which is part of the drug as a preservative.
Do not exceed the recommended dose, especially in children and the elderly.
Effects on ability to drive and use machinery
With long-term treatment or use of the drug at higher doses can not rule out the possibility of systemic effects on the cardiovascular system that may impair the ability to drive and use machinery.