anastrozole dosage

Tetryzoline sympathomimetics group refers to straight and has a stimulating effect on anastrozole dosage receptors of the sympathetic nervous system. Thus it has no or almost no effect on beta-adrenergic receptors. As a sympathomimetic amine drug has vasoconstrictor and anti-edema action in contact with the nasal mucosa, which leads to a narrowing of the small arterioles of the nasal passages, to reduce swelling of the nasal mucosa and reduced secretion.
Vasoconstrictor effect and decrease mucosal edema influenced tetryzoline begins after approximately one minute after topical drug and lasts 4-8 hours.

Pharmacokinetics

When applied topically, and the recommendations on the use of absorption of the drug tetryzoline practically does not occur.

Indications

To reduce swelling of the nasal mucosa in patients suffering from rhinitis, pharyngitis, sinusitis, hay fever, and to reduce swelling of the nasal mucosa when necessary diagnostic and therapeutic measures.

Contraindications

 

  • Hypersensitivity to any component of the drug;
  • dry rhinitis;
  • angle-closure glaucoma;
  • Tizin 0.1% for adults is contraindicated in children under 6 years;
  • Tizin 0.05% for children is contraindicated in children under 2 years old.

Carefully

In patients with severe cardiovascular disease (such as coronary heart disease anastrozole dosage, hypertension, arrhythmia, aneurysm, pheochromocytoma), with metabolic disorders (such as hyperthyroidism, diabetes), and in patients taking  inhibitors or other drugs that increase blood pressure , Tizin can be used only after a careful comparison of the potential benefits and risks for the patient.

Pregnancy and lactation

Since there is the risk of systemic side effects (mainly vasoconstrictor effect), use of the drug during pregnancy and lactation is possible only after a careful comparison of the potential benefits to the mother and the risk to the fetus (child).

Dosing and Administration

Tizin nasal drops 0.1% for adults
If there are no other requirements, the adults and children over 6 years appoint 2-4 drops of the drug in each nostril 3-5 times a day.

Tizin nasal drops 0.05% for children
if there are no other regulations, children aged 2 to 6 years appoint 2-3 drops of the drug in each nostril 3-4 times a day.

Tizin should be applied no more than 1 time per 4 hours.
As a rule, a rare use of the drug is enough, because in most cases, the drug has a long-term effect (often up to 8 hours). A single administration of the drug at bedtime relieves nasal congestion overnight, but it can cause insomnia due to the impact tetryzoline anastrozole dosage.
Tizin can be used for a short time. The duration of treatment should be not more than 5 days for adults and not more than 3 days for children. Re-medication can be prescribed only after a few days.

Side effect

Reactive hyperemia, burning sensation mucosal, chronic swelling of nasal mucosa with long-term use of the drug, it is sometimes possible systemic effects (palpitations, headaches, insomnia, tremor, weakness, sweating, increased blood pressure, nausea, allergic reactions).
Excessive use or prolonged ( more than 5-7 days) tetryzoline application and use of the drug in high doses can lead to a feeling of burning and dryness of the nasal mucosa, as well as the development of reactive edema and rhinitis medication.
Long-term use of imidazole derivatives can have a damaging effect on the mucous membrane, inhibiting the activity of ciliated epithelium. Irreversible damage to the mucosa can lead to dry rhinitis.

Overdose

The risk of systemic side effects is high in young children in contact with the drug inside.
Excess systemic absorption of alpha-sympathomimetic imidazole derivatives may result in depression of the central nervous system, which is manifested by drowsiness, decrease in body temperature, bradycardia, hypotension, apnea and coma.
To the usual symptoms of overdose include mydriasis, nausea, cyanosis, fever, convulsions, tachycardia, cardiac arrhythmia, heart failure, hypertension, pulmonary edema, respiratory distress, mental disorders.
Antidote tetryzoline hydrochloride is not known.
Treatment: the appointment of activated charcoal, gastric lavage, oxygen and antipyretics anticonvulsants and means if necessary. In order to reduce blood pressure is prescribed at 5 mg phentolamine in saline / slow or 100 mg orally. Vasoconstrictor drugs are contraindicated in hypotension.

Effects on ability to drive and use machines

Too prolonged use of medication or the use of doses higher than recommended, may develop systemic cardiovascular effects. Systemic side effects may lead to a disruption of the ability to control a car or operating machinery.

Interaction with other drugs

The combined use of anastrozole dosage monoamine oxidase inhibitors and tricyclic antidepressants can lead to high blood pressure as a result of potentiation of the vasoconstrictive effect.