After oral administration of ornidazole is rapidly absorbed. The average absorption is 90%. Maximum plasma concentrations are reached within 3 hours.
The binding of ornidazole with anastrozole the proteins is approximately 13%. Active substance tiberal very well into the cerebrospinal fluid, and other body fluids and tissues.
Ornidazole plasma concentrations are in the optimal range for the various indications. Cumulation factor after receiving multiple doses of 500 mg or 1000 mg in healthy volunteers after every 12 hours is equal to 1.5-2.5.
Ornidazole is metabolized in the liver to form mainly hydroxymethyl-2 and a -gidroksimetilmetabolitov. Both metabolites are less active against Trichomonas vaginalis and anaerobic bacteria than the unmodified ornidazole.
The half-life is about 13 hours. After a single oral dose is excreted 85% in the first 5 days, mainly as metabolites. About 4% of the dose is eliminated via the kidneys in unchanged form.
Trichomoniasis (urinary infections in women and men caused by Trichomonas vaginalis); amebiasis (all of intestinal infections caused by Entamoeba histolytica, including amoebic dysentery, and all forms of extra-intestinal amebiasis, especially amebic liver abscess); giardiasis.
Mode of application
Tiberal always taken after meals.
2 1 tablet twice a day (morning and evening) for 5 days.
To eliminate the possibility of re-infection, the sexual partner, in all cases, should receive the same treatment.
The daily dose anastrozole for children is 25 mg / kg body weight and is administered once.
Hypersensitivity to the drug or other nitroimidazole derivative.
Weakly expressed drowsiness, headaches and gastrointestinal disorders (nausea). In some cases side effects, such as dizziness, tremor, rigidity, loss of coordination, convulsions, fatigue, temporary loss of consciousness, signs of sensory or mixed peripheral neuropathy. There have been cases of perversion of taste sensations, changes in liver function tests, skin reactions and hypersensitivity reactions.
Care should be taken in patients with anastrozole diseases such as epilepsy, brain lesions, multiple sclerosis. If you exceed the recommended doses there is a risk in patients with liver disease, alcohol abuse, pregnant and lactating mothers and children.
Pregnancy and lactation
Extensive research on the different kinds of animals did not reveal any teratogenic or toxic effect of the drug on the fetus. Controlled studies in pregnant women have been conducted. However, for general health reasons appoint Tiberal early in pregnancy or nursing mothers only if absolutely indicated.
Unlike other nitroimidazole derivative, ornidazole did not inhibit aldehyde dehydrogenase and is therefore incompatible with alcohol. However, ornidazole potentiates the anastrozole action of oral anticoagulants coumarin, which requires their respective dose adjustment. Ornidazole lengthens muscle relaxant action of vecuronium bromide.